Wang J.C. Untangling the double helix: DNA entanglement and the action of the DNA topoisomerases. - Cold Spring Harbor: Cold Spring Harbor Laboratory Press, 2009. - xi, 233 p.: ill. (some col.). - Ind.: p.222-233. - ISBN 978-0-87969-863-8; ISBN 978-0-87969-879-9

Оглавление / Contents

Preface ........................................................ ix 1 An Insuperable Problem ....................................... 1 2 Nature's Solutions: The DNA Topoisomerases .................. 15 3 Breaking a DNA Strand and Holding on to the Broken Ends ..... 31 4 A Magic Swivel .............................................. 55 5 Moving One DNA Double Helix through Another.................. 71 6 Real-Time Viewing of the DNA Topoisomerases in Action ...... 101 7 Manifestations of DNA Entanglement: Replication and Recombination .............................................. 123 8 Manifestations of DNA Entanglement: Gene Expression ........ 149 9 Beyond DNA Entanglement: New Twists on an Old Theme ........ 165 10 From Nature's Battlefields to the Clinical Wards ........... 185 Appendix I Identification of the Covalent Intermediates in Topoisomerase-Catalyzed Reactions ............................. 211 Appendix 2 Catalysis of DNA Breakage and Rejoining by DNA Topoisomerases ................................................ 217 Index ......................................................... 223